TREM Receptors Connecting Bowel Inflammation to Neurodegenerative Disorders
نویسندگان
چکیده
منابع مشابه
Multiple dopamine receptors: relevance for neurodegenerative disorders.
In several neurodegenerative disorders such as Parkinson’s disease and Huntington’s disease, neuronal systems employing the neurotransmitter dopamine have been implicated in either the pathology or the drug treatments of the disease (for review see [ 11). It is therefore of some importance to understand the mechanism of action of dopamine in controlling brain function, both in the normal state ...
متن کاملTREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases.
Triggering receptor expressed on myeloid cells-1 (TREM-1) potently amplifies acute inflammatory responses by enhancing degranulation and secretion of proinflammatory mediators. Here we demonstrate that TREM-1 is also crucially involved in chronic inflammatory bowel diseases (IBD). Myeloid cells of the normal intestine generally lack TREM-1 expression. In experimental mouse models of colitis and...
متن کاملAstrocyte as the Modulator in Brain Inflammation and Neurodegenerative Disorders
Cite this article: Hsieh HL, Yang CM (2016) Astrocyte as the Modulator in Brain Inflammation and Neurodegenerative Disorders. Ann Neurodegener Dis 1(2): 1008. *Corresponding author Hsi-Lung Hsieh, Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, 261 Wen-Hua 1st Road, Gui-Shan, Tao-Yuan, Taiwan, Tel: (03) 2118999 EXT 5421; Fax: (03) 2118...
متن کاملCannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders.
The G-protein coupled receptors for Δ⁹-tetrahydrocannabinol, the major psychoactive principle of marijuana, are known as cannabinoid receptors of type 1 (CB₁) and 2 (CB₂) and play important functions in degenerative and inflammatory disorders of the central nervous system. Whilst CB₁ receptors are mostly expressed in neurons, where they regulate neurotransmitter release and synaptic strength, C...
متن کاملAggregation propensity of neuronal receptors: potential implications in neurodegenerative disorders
Misfolding and aggregation of proteins in tissues is linked to the onset of a diverse set of human neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. In these pathologies proteins usually aggregate into highly ordered and β-sheet enriched amyloid fibrils. However, the formation of these toxic structures is not restricted to a reduced set of polypeptides but rather an i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cells
سال: 2019
ISSN: 2073-4409
DOI: 10.3390/cells8101124